EARLY PREDICTORS OF RENAL DYSFUNCTION IN Β-THALASSEMIA MAJOR AND INTERMEDIA PATIENTS
نویسندگان
چکیده
منابع مشابه
Early Predictors of Renal Dysfunction in Egyptian Patients with β-Thalassemia Major and Intermedia
BACKGROUND Better survival of thalassemia patients allowed previously unrecognized renal complications to emerge. OBJECTIVES Assess prevalence and early predictors of renal dysfunction in young β-thalassemia major (β-TM) and intermedia (β-TI) patients. SUBJECTS 66 β-TM (group I), 26 β-TI (group II) Egyptian patients and 40 healthy controls. METHODS Clinical assessment and laboratory data ...
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Improved survival among transfusion dependent thalassemia patients in recent years has led to the manifestation of morbidities such as renal dysfunction. Renal injury is still an underestimated complication in β thalassemia major patients. Chronic anemia, iron overload due to repeated transfusion, and specific iron chelators are the main factors in pathogenesis of renal dysfunction in β thalass...
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Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...
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Background Sickle hemoglobin is the most common abnormal hemoglobin in the United States. Hemoglobin S arises as a result of a single amino acid substitution (glutamic acid to valin at position 6 of the β-globine chain). The presence of fetal hemoglobin (HbF) plays a relatively protective role since a significant amount of HbF interferes with HbS polymerization, the pathogenesis mechanism of ...
متن کاملEvaluation of endocrine dysfunction in thalassemia intermedia
Introduction: Thalassemia is an inherited disease which leads to an imbalance of globinchain synthesis and consequently, ineffective hematopoiesis. Iron deposits in many important body organs, as endocrine organs due to blood transfusion or ineffective hematopoiessis. The aim of the present study is to assess the endocrine disorders in the patients with thalassemia intermedia referred to ...
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ژورنال
عنوان ژورنال: Mediterranean Journal of Hematology and Infectious Diseases
سال: 2004
ISSN: 2035-3006
DOI: 10.4084/mjhid.2014.057